ARTS2
Summary of ARTS2 results from project: [mq_saccharopolyspora]
Description
This report presents the results from ARTS2 (Antibiotic Resistant Target Seeker Version 2), a bioinformatic tool for targeted genome mining of antibiotic resistance targets. The analysis focused on identifying genes with signatures of antibiotic resistances, gene duplication, horizontal gene transfer, and proximity to biosynthetic gene cluster (BGC).
Here, only ARTS2 profile with BGC proximity are shown.
Table Description:
- Dup: Uncommon gene duplication. Highlight potential repurposed primary metabolism genes.
- Res: Hits to known resistance models.
- BGC: Cross reference locations or proximity to secondary metabolite BGCs.
- HGT: Phylogenetic incongruence. Highlight essential genes with evidence of inter-genus horizontal gene transfer (HGT).
| index | profile | name | product | function | hits | Dup | HGT | Res | BGC | BGC ID | Genome ID |
|---|---|---|---|---|---|---|---|---|---|---|---|
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A total of 311 BGCs from 25 genomes were found to have hits with 133 ARTS2 profile.
References
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Mungan,M.D., Alanjary,M., Blin,K., Weber,T., Medema,M.H. and Ziemert,N. (2020) ARTS 2.0: feature updates and expansion of the Antibiotic Resistant Target Seeker for comparative genome mining. Nucleic Acids Res.,10.1093/nar/gkaa374
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Alanjary,M., Kronmiller,B., Adamek,M., Blin,K., Weber,T., Huson,D., Philmus,B. and Ziemert,N. (2017) The Antibiotic Resistant Target Seeker (ARTS), an exploration engine for antibiotic cluster prioritization and novel drug target discovery. Nucleic Acids Res.,10.1093/nar/gkx360